In a technological landscape where Artificial Intelligence (AI) reshapes business operations, "Mastering AI Integration in Enterprises" offers a structured roadmap for adopting AI, anchored in systems engineering principles. This 60-minute talk highlights the need for a systematic approach to align AI with organizational culture, processes, and workforce development. We introduce systems engineering as a framework for managing AI integration complexities, focusing on developing a flexible, tailored learning strategy roadmap. Key elements include a needs assessment, customized learning plans, and agile implementation with continuous feedback. Real-world case studies will provide practical insights into the successes and challenges of AI adoption. The talk concludes with strategies to navigate potential obstacles, emphasizing agility and adaptability. Aimed at professionals and decision-makers in the AI and Agile fields, this presentation is a guide for the transformative journey of AI adoption in enterprises.